Barrier Impairment and Type 2 Inflammation in Allergic Diseases: The Pediatric Perspective
Allergic diseases represent a global burden.Although the patho-physiological mechanisms are still poorly understood, epithelial barrier dysfunction and Th2 inflammatory response play knife set a pivotal role.Barrier dysfunction, characterized by a loss of differentiation, reduced junctional integrity, and altered innate defence, underpins the patho